Pesquisa | Portal de Pesquisa da BVS

1.

Beyond the Triplet Code: Context Cues Transform Translation.

Brar, Gloria A.

Cell ; 167(7): 1681-1692, 2016 Dec 15.

Artigo em Inglês | MEDLINE | ID: mdl-27984720

2.

Gametogenesis: Exploring an Endogenous Rejuvenation Program to Understand Cellular Aging and Quality Control.

Sing, Tina L; Brar, Gloria A; Ünal, Elçin.

Annu Rev Genet ; 56: 89-112, 2022 11 30.

Artigo em Inglês | MEDLINE | ID: mdl-35878627

3.

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Gilbert, Luke A; Larson, Matthew H; Morsut, Leonardo; Liu, Zairan; Brar, Gloria A; Torres, Sandra E; Stern-Ginossar, Noam; Brandman, Onn; Whitehead, Evan H; Doudna, Jennifer A; Lim, Wendell A; Weissman, Jonathan S; Qi, Lei S.

Cell ; 154(2): 442-51, 2013 Jul 18.

Artigo em Inglês | MEDLINE | ID: mdl-23849981

4.

Ribosome profiling reveals the what, when, where and how of protein synthesis.

Brar, Gloria A; Weissman, Jonathan S.

Nat Rev Mol Cell Biol ; 16(11): 651-64, 2015 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-26465719

5.

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.

Guenther, Ulf-Peter; Weinberg, David E; Zubradt, Meghan M; Tedeschi, Frank A; Stawicki, Brittany N; Zagore, Leah L; Brar, Gloria A; Licatalosi, Donny D; Bartel, David P; Weissman, Jonathan S; Jankowsky, Eckhard.

Nature ; 559(7712): 130-134, 2018 07.

Artigo em Inglês | MEDLINE | ID: mdl-29950728

6.

Rules are made to be broken: a "simple" model organism reveals the complexity of gene regulation.

Higdon, Andrea L; Brar, Gloria A.

Curr Genet ; 67(1): 49-56, 2021 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-33130938

7.

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.

Berchowitz, Luke E; Gajadhar, Aaron S; van Werven, Folkert J; De Rosa, Alexandra A; Samoylova, Mariya L; Brar, Gloria A; Xu, Yifeng; Xiao, Che; Futcher, Bruce; Weissman, Jonathan S; White, Forest M; Amon, Angelika.

Genes Dev ; 27(19): 2147-63, 2013 Oct 01.

Artigo em Inglês | MEDLINE | ID: mdl-24115771

8.

Strategies and Challenges in Identifying Function for Thousands of sORF-Encoded Peptides in Meiosis.

Hollerer, Ina; Higdon, Andrea; Brar, Gloria A.

Proteomics ; 18(10): e1700274, 2018 05.

Artigo em Inglês | MEDLINE | ID: mdl-28929627

9.

Proto-genes and de novo gene birth.

Carvunis, Anne-Ruxandra; Rolland, Thomas; Wapinski, Ilan; Calderwood, Michael A; Yildirim, Muhammed A; Simonis, Nicolas; Charloteaux, Benoit; Hidalgo, César A; Barbette, Justin; Santhanam, Balaji; Brar, Gloria A; Weissman, Jonathan S; Regev, Aviv; Thierry-Mieg, Nicolas; Cusick, Michael E; Vidal, Marc.

Nature ; 487(7407): 370-4, 2012 Jul 19.

Artigo em Inglês | MEDLINE | ID: mdl-22722833

10.

Emerging roles for centromeres in meiosis I chromosome segregation.

Brar, Gloria A; Amon, Angelika.

Nat Rev Genet ; 9(12): 899-910, 2008 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-18981989

11.

Truncated protein isoforms generate diversity of protein localization and function in yeast.

Higdon, Andrea L; Won, Nathan H; Brar, Gloria A.

Cell Syst ; 15(4): 388-408.e4, 2024 Apr 17.

Artigo em Inglês | MEDLINE | ID: mdl-38636458

12.

Dbp1 is a low performance paralog of RNA helicase Ded1 that drives impaired translation and heat stress response.

Powers, Emily N; Kuwayama, Naohiro; Sousa, Camila; Reynaud, Kendra; Jovanovic, Marko; Ingolia, Nicholas T; Brar, Gloria A.

bioRxiv ; 2024 Jan 14.

Artigo em Inglês | MEDLINE | ID: mdl-38260653

13.

Truncated protein isoforms generate diversity of protein localization and function in yeast.

Higdon, Andrea L; Won, Nathan H; Brar, Gloria A.

bioRxiv ; 2023 Jul 14.

Artigo em Inglês | MEDLINE | ID: mdl-37503254

14.

Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis.

Brar, Gloria A; Kiburz, Brendan M; Zhang, Yi; Kim, Ji-Eun; White, Forest; Amon, Angelika.

Nature ; 441(7092): 532-6, 2006 May 25.

Artigo em Inglês | MEDLINE | ID: mdl-16672979

15.

Meiotic cDNA libraries reveal gene truncations and mitochondrial proteins important for competitive fitness in Saccharomyces cerevisiae.

Sing, Tina L; Conlon, Katie; Lu, Stephanie H; Madrazo, Nicole; Morse, Kaitlin; Barker, Juliet C; Hollerer, Ina; Brar, Gloria A; Sudmant, Peter H; Ünal, Elçin.

Genetics ; 221(2)2022 05 31.

Artigo em Inglês | MEDLINE | ID: mdl-35471663

16.

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

Nguyen, Hanh H; Aronchik, Ida; Brar, Gloria A; Nguyen, David H H; Bjeldanes, Leonard F; Firestone, Gary L.

Proc Natl Acad Sci U S A ; 105(50): 19750-5, 2008 Dec 16.

Artigo em Inglês | MEDLINE | ID: mdl-19064917

17.

Global mapping of translation initiation sites by TIS profiling in budding yeast.

Hollerer, Ina; Powers, Emily N; Brar, Gloria A.

STAR Protoc ; 2(1): 100250, 2021 03 19.

Artigo em Inglês | MEDLINE | ID: mdl-33458709

18.

Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast.

Eisenberg, Amy R; Higdon, Andrea L; Hollerer, Ina; Fields, Alexander P; Jungreis, Irwin; Diamond, Paige D; Kellis, Manolis; Jovanovic, Marko; Brar, Gloria A.

Cell Syst ; 11(2): 145-160.e5, 2020 08 26.

Artigo em Inglês | MEDLINE | ID: mdl-32710835

19.

Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells.

Hollerer, Ina; Barker, Juliet C; Jorgensen, Victoria; Tresenrider, Amy; Dugast-Darzacq, Claire; Chan, Leon Y; Darzacq, Xavier; Tjian, Robert; Ünal, Elçin; Brar, Gloria A.

G3 (Bethesda) ; 9(4): 1045-1053, 2019 04 09.

Artigo em Inglês | MEDLINE | ID: mdl-30723103

20.

Angelika Amon.

Brar, Gloria A; Ünal, Elçin.

Dev Cell ; 55(5): 525-528, 2020 12 07.

Artigo em Inglês | MEDLINE | ID: mdl-33290693

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Beyond the Triplet Code: Context Cues Transform Translation.

Gametogenesis: Exploring an Endogenous Rejuvenation Program to Understand Cellular Aging and Quality Control.

CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

Ribosome profiling reveals the what, when, where and how of protein synthesis.

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs.

Rules are made to be broken: a "simple" model organism reveals the complexity of gene regulation.

A developmentally regulated translational control pathway establishes the meiotic chromosome segregation pattern.

Strategies and Challenges in Identifying Function for Thousands of sORF-Encoded Peptides in Meiosis.

Proto-genes and de novo gene birth.

Emerging roles for centromeres in meiosis I chromosome segregation.

Truncated protein isoforms generate diversity of protein localization and function in yeast.

Dbp1 is a low performance paralog of RNA helicase Ded1 that drives impaired translation and heat stress response.

Truncated protein isoforms generate diversity of protein localization and function in yeast.

Rec8 phosphorylation and recombination promote the step-wise loss of cohesins in meiosis.

Meiotic cDNA libraries reveal gene truncations and mitochondrial proteins important for competitive fitness in Saccharomyces cerevisiae.

The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

Global mapping of translation initiation sites by TIS profiling in budding yeast.

Translation Initiation Site Profiling Reveals Widespread Synthesis of Non-AUG-Initiated Protein Isoforms in Yeast.

Evidence for an Integrated Gene Repression Mechanism Based on mRNA Isoform Toggling in Human Cells.

Angelika Amon.